Are you doing a ton of status? If you go crazy with status of Memory Views, Ladder Views, Data Views, lots of Code Blocks with Status turned ON in the Project Browser, Designer will govern the comm server request when the GUI starts to get slow. Logging of Trend Views can slow down a PC if you are doing a ton of that at very high frequency. That's not fool proof, but, like I said, only if you are bogging down the app like crazy.
If this is true, turn off some status or close some views.