I timed the XRef query for the popup. In Debug build, it takes nearly a second (900+ms). However, in Release build, it only takes ~40ms. You might see a slight delay (25 Hz refresh rate ain't too bad).
However, I am on a pretty powerful PC, and this is with NO STATUS on (I am not connected to a PLC).
If you are doing a bunch of status, and a huge XRef database, your navigation could be slow.
What kind of PC do you have? How many processors/cores/threads and memory?
If it's an older PC, you can definitely see Designer slow down to a crawl with some Trend Views, Data Views, 20 code blocks doing Status, and XRef queries on a single or dual core with 4G of RAM. I have 8 cores, dual thread (so 16 logical processors) and 16 GB of RAM.