SIM was detecting Virtual com ports that were used by Bluetooth settings (Bluetooth headphones).
Removed com ports from Bluetooth settings, and now SIM starts great, and sees no com ports.

Tried to change INI to turn AutoSence off, but can not save file,and will not allow me to change read only setting in Windows folder (as an administrator). Will have to find out how to save to the Windows folder.
Would still rather have Autosense on/off be a feature in DmDesigner.