The issue is that newer versions of Windows are somewhat arbitrary on which port they send broadacasts to. The pick-a-NIC feature apparently has a bug (this is the second time I've heard this) but we haven't been able to duplicate it to fix it. This is what caused your NetEdit crash. Changing the priority doesn't seem to be helpful, only selecting the correct NIC, which is apparently crashing. DNLoader was never updated to support pick-a-NIC, although I'm pretty sure it would be crashing too.
I'm certain we have an FAQ on this multi-NIC issue, but generally the answers involve disabling the offending NIC long enough to do what you need. For older systems, using IPX protocol was a good answer, but newer Windows system don't support IPX.
I'll locate the FAQ and post the link back here.