SETB (actually SET in DirectSOFT) is an instruction in the PLC. You can programatically set and reset bits using
SET B2000.1
RST B2000.15
However, you cannot use the DirectSOFT Data View and use COMMUNICATIONS to set or reset bits (because of what I described above).
You can OUT, SET, RST to Bit-of-word programatically.
The original post showed an error message from the data view in DirectSOFT "Element is read only", and my explanation dealt with using DirectSOFT's Data View to change a bit of word. However, I incorrectly implied that you could not change it PERIOD.

This is definitely wrong.
You DEFINITELY can set it using OUT, SET and RST instructions in your PLC program, along with looking at their states in contacts using B2000.1 in a contact (just like X0), just as 8bits asked about

Note that DirectSOFT uses OUT, SET, RST, not the handheld programmer instructions (OUTB, SETB, RSTB) because we have you enter bit of word as a single parameter Bvaddress.bitnumber where vaddress is a V memory address (without the "V") and bitnumber is a value 0..15 (decimal) corresponding to the bit number.
So, to SET bit 10 (the 11th bit) of V2000, you would do
SET B2000.10
In the handheld programmer, I think this would be a 2 parameter instruction with the V parameter and the K bit number (in decimal???)
SETB V2000 K10