DHCP on your PC (Client) is OK.
DHCP on your PLC (Server) is usually NOT good (because the assigned IP Address can change, and Designer's Connection Link cannot resolve its mapped IP Address).
Do-more Designer can handle multiple subnets on your PC. The Select Connection/Link dialog lets you choose the set of NIC/Subnets to support. You typically have just 1 subnet for your OT and a DIFFERENT subnet for your IT. Make sure the subnets are DIFFERENT (not just a different IP Address), e.g.
192.168.10.9 subnet mask 255.255.0.0 (so subnet 192.168.x.x)
172.10.1.42 subnet mask 255.255.255.0 (subnet 172.10.1.x)
172.10.2.42 subnet mask 255.255.255.0 (subnet 172.10.2.x)
Hit the Select Ethernet Networks button and check the one(s) with PLCs on them, and UNcheck the ones without.