Yes. Do-more supports Run Time Edit.
If you are wanting some kind of "write project" protection - look at the User/Password capability of Do-more. The default (no password) default is read/write data, read/write program. You can change the Default to be read/write data, read program (not read/write program). Designer will still let you "edit" the program and save it to disk, but it would not let you (as the Default user) to write the program.
Is this the kind of functionality you are wanting?