We realize the tradeoffs of text size vs. screen real estate. It's hard to find the perfect balance across all resolutions and monitors. I have seen monitors that the text is crisp and readable at 100%. I have seen other monitors where the status element text is not very good. I've even seen both at the same time on PCs with multiple monitors (not all monitors are equal).
Zooming is the first "work around", as you have figured out, but this also zooms everything else, which is not always good.
One other possibility is for you to tweak your DmDesignerx_x.ini file's font setting. By default, it is set to Arial 10. You may try Arial 11. That is a 10% bump on the point size, which may render better with your system at 100% or even 125%.
In Designer's Launch Pad's Application's pane, look for your version's DmDesignerx_x.ini "app" (e.g. DmDesigner2_2.ini for 2.2). Run that. It will open it up in Notepad. Look for the [Fonts] section. You want to tweak the Workspace Font entry:
Workspace Font=Arial:11
Save your INI file and close Notepad. Then shut down Designer and re-launch to check it out. You can try 12, or even 9 but at 125% zoom (you can tweak the default zoom in Ladder Options). This just gives you different "detent" on the actual font sizes (Designer utilizes tenths of a point, e.g. 125% of 11 point font base results in 13.7pt)