I played it as a kid on my very first computer. I had it on 5.25 Floppy. My computer was pretty BA back then. DUAL 5.25" floppy disks and 512KB RAM. Monochrome Amber monitor and a daisywheel printer. We even had a 14.4k modem (that you actually had to set the phone on!) *sigh* The good ole days.
On topic, I just searched for DMDesigner.exe in the registry, and took out the quotation marks, and it works great in Windows 10 Enterprise. It had two instances I had to edit.