It's the week of nonsense problems!

Had a BRX suddenly stop accepting MTCP writes today, but still talks to other MTCP clients, and will even talk to those same nodes for DMD
System:- Customer's PC sets MC bits in BRX to request specific recipes
- HMI talks MTCP to BRX
- No POM
- BRX configured for 10 MTCP sessions, 60 second timeout, port 502
- All nodes on main site network. Estimate probably under 100 nodes, including PC, IP cameras, etc.
History and current observations:- Been working fine for a couple months
- HMI still talking fine
- DMD, installed today for troubleshooting on another PC in subnet ("Manager's PC"), communicates with BRX fine
- Modbus Poll on Manager's PC reports no response from BRX to either write/poll MC's and continuous polling of MHRs.
- Tried cycling BRX with no improvement
- Customer Wiresharked the normal client PC requesting jobs. There are some transactions both to and from BRX (ACKs, SYNs and so forth) , but no response to the actual MTCP write packets. PCAP file has been emailed. BRX IP is 192.168.35.80.
So the BRX seems to be not accepting Modbus writes, but only selectively; HMI still writes, reads, everything.
ModbusTCPServer.Transactions is incrementing wildly, but the HMI polls pretty fast. .Errors and .LastError both at 0. Any ideas or anything else to check? I proposed temporarily disconnecting the HMI but with the client PC not able to send jobs, the HMI is the only safety net, so they don't want to disconnect it, even temporarily.