I seriously doubt "there is some software running in the back ground it doesn't like", but perhaps. Yours is the only one that we know of with this symptom. Something, therefore, seems to be unique to your PC. So...
Some questions:
1. What make & model is your PC?
2. What Windows OS do you have?
3. How much RAM does your PC have?
4. How fast is your PC?
5. What Do-more Designer version do you have? (Help --> About)
6. What Do-more PLC versions do you have? (There are 4 different versions in PLC --> System Information)
7. Are you editing/downloading System Configuration/Memory Configuration changes? Or just program changes?
8. Are you online by serial, USB or Ethernet?
9. Have you tried another PC?
10. Have you tried ONLY downloading changes with Status OFF?